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Pan-European interdisciplinary network to identify genetic factors (human genetics, epigenetics, metagenomics) contributing to IBS etiopathogenesis


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An action in the Biomedicine and Molecular Biosciences (BMBS) domain

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within COST (European Cooperation in Science and Technology)

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of the European Science Foundation

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in the European Union

Phenotyping Tool


Within the COST Action BM1106 GENIEUR the interdisciplinary team of clinical colleagues and basic scientists from WG1 and 2 but also 3 und 4 developed the phenotyping tool for deep characterisation of IBS patients and healthy controls comprising

1. The Case Report Forms (CRF)

2. A set of questionnaires for assessment not only of the gastrointestinal phenotype but also comorbid conditions such as upper GI symptoms, pain somatization as well as psychiatric symptoms such as anxiety and depression.

The selected questionnaires can be accessed via the following sites:

  • Rome III modular questionnaires for IBS and functional dyspepsia
    >> Translations in most European languages available
  • Global symptom rating scale-IBS (GSRS-self; GSRS-IBS): The copyright holder of the scale is Astra Zeneca and any request should be addressed to this
    The GSRS-IBS is only available in English (US), English (UK), Norwegian, and Swedish.
    Below please find a table listing all available GSRS-Self translations:
    Afrikaans-South Africa
    English-Australia
    Dutch-Belgium
    French-Belgium
    Portuguese-Brazil
    English-Canada
    French-Canada
    Chinese-Taiwan
    Czech-Czech Republic
    Danish-Denmark
    Finnish-Finland
    French-France
    French-Switzerland
    German-Switzerland
    German-Austria
    German-Germany
    Greek-Greece
    Chinese-Hong Kong
    Hungarian-Hungary
    Icelandic-Iceland
    Italian-Switzerland
    Italian-Italy
    Japanese-Japan
    Korean-Korea
    Spanish-Mexico
    Norwegian-Norway
    Polish-Poland
    Portuguese-Portugal
    Romanian-Romania
    Spanish-Spain
    Swedish-Finland
    Swedish-Sweden
    Dutch-Netherlands
    Farsi-Iran
    Turkish-Turkey
    English-UK
    English-South Africa
    English-US
    Spanish-US
    Spanish-Argentina
    Russian-Russia
    Slovak-Slovakia
  • Visceral Sensitivity Index
    Please contact Jennifer Labus () >> English only (no translations available)
  • Nepean Dyspepsia Index is available via MAPI
  • GAD-7 >>translations in nearly 80 languages available
  • Patient Health Questionnaire-9 >> Translations in nearly 80 languages available
  • Patient Health Questionnaire-15 >> Translations in nearly 80 languages available

3. The following Standard Operation Procedures (SOPs) for functional testing

4. The following SOPs for patient material sampling